| abstract |
The present invention relates to a pyrimido [5,4-b] indolizine or pyrimido [5,4-b] pyrrolidine compound, a production method and use thereof. The compounds of the present invention have good inhibitory activity on BTK at molecular and cellular level. Importantly, the compounds of the present invention have low activity on Ramos cells, normal human B lymphoma cells, but high activity on BTK sensitive human diffuse large B lymphoma TMD8 cells. This indicates that these compounds having a novel structure have relatively high selectivity, have few off-targets and their corresponding side effects, and are one of the promising selective BTK inhibitors for development. [Selection diagram] None |