| abstract |
The present invention relates to compounds of formula I that inhibit Rho-kinase, a bicyclic dihydropyrimidinecarboxamide derivative, methods of preparing such compounds, pharmaceutical compositions containing them and their therapeutic uses. The compounds of the present invention are useful in many disorders associated with ROCK enzyme mechanisms such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary diseases including idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH). May be particularly useful in the treatment of [Selection diagram] None |