| abstract |
The present invention relates to 1,3-disubstituted-1H-pyrazolo [3,4-d] pyrimidin-4-amine derivatives, 5,7-disubstituted-pyrrolo [2,1-f] [1,2,4]. The present invention relates to a triazine-4-amine derivative or a 5,7-disubstituted-imidazo [5,1-f] [1,2,4] triazin-4-amine derivative, and a pharmaceutically acceptable salt thereof. The compounds are enhancers of the cystic fibrosis transmembrane conductance regulator (CFTR). The present invention also discloses pharmaceutical compositions comprising the compound, optionally in combination with additional therapeutic agents, and methods of enhancing CFTR in mammals, including humans, by administering the compound. These compounds are useful in cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, diabetes, dry eye disease, pancreatitis, rhinosinusitis, Sjogren's syndrome and other CFTR-related Useful for treating disorders. [Selection diagram] None |