| abstract |
PROBLEM TO BE SOLVED: To provide an agent for suppressing 25-OHC-induced cell death. A 25-OHC-induced cell death inhibitor, including an ACAT inhibitor. ACAT inhibitors are, for example, K-604, F12511 or CS-505. It is also possible to include α-tocopherol. Drugs, including 25-OHC-induced cell death inhibitors, are used for the prevention and / or treatment of neurogenic diseases. Neurogenic diseases include amyotrophic lateral sclerosis (ALS), motor neuron disease (MND), peripheral neuropathy, myasthenia gravis, and congenital myasthenia gravis. [Selection diagram] Fig. 4 |