| abstract |
PROBLEM TO BE SOLVED: To provide a macrocyclic compound having better ALK kinase inhibitory activity and / or having better pharmacodynamic / pharmacokinetic properties, and a pharmaceutical composition containing the compound. SOLUTION: A substituted macrocycle compound or a crystal form thereof, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate or a compound represented by the following formula is a typical example. Solvation product. [Effect] The compound of the present invention has an excellent inhibitory property on protein kinase (for example, ALK kinase) as compared with the prior art. This deuteration technique alters the metabolism of a compound in vivo, allowing the compound to have better pharmacokinetic parameters. [Selection diagram] None |