abstract |
PROBLEM TO BE SOLVED: To provide a liposome used for non-viral delivery of RNA for eliciting a defensive immune response in a vertebrate. A liposome having a lipid bilayer encapsulating an aqueous core, wherein (i) the lipid bilayer comprises a lipid having a tertiary amine and is in the range 5.0-7.6. It has a pKa; and (ii) the aqueous core contains an RNA encoding an immunogen. These liposomes can have an essentially neutral surface charge at physiological pH and are effective for immunity. [Selection diagram] None |