| abstract |
PROBLEM TO BE SOLVED: To respond to a modulation of expression and / or activity of a cadherin-binding protein β1 (CTNNB1) gene and / or to modulate a β-catenin gene expression pathway in a compound, composition, and method. Provided. SOLUTION: This is a double-stranded low molecular weight interfering nucleic acid (siNA) molecule that inhibits the expression of CTNNNB1, and the siNA contains a sense strand and an antisense strand, and the sense strand is 5'-CUGUUGGAUGAUCGAAA-3'. The antisense strand comprises the nucleotide sequence of 5'-UUCGAAUCAAUCCAACAG-3', a siNA molecule. [Selection diagram] Fig. 1 |