| abstract |
PROBLEM TO BE SOLVED: To provide an improved means and method for delivery of a target therapeutic action molecule to the cytoplasm of a cell. SOLUTION: The denguevirus glycoprotein E contains (a) a targeting moiety; (b) a specific amino acid sequence or a sequence showing 1 to 8 substitutions, deletions, or insertions as compared to a specific amino acid sequence. A construct comprising a membrane fusion moiety consisting of one or more membrane fusion sequences from which it is derived; (c) a molecule to be delivered to the cytoplasm of a cell, or the construct and optionally a pharmaceutically acceptable carrier. A pharmaceutical composition comprising, or one or more derived from Dengvirus glycoprotein E, comprising a specific amino acid sequence or a sequence showing 1 to 8 substitutions, deletions, or insertions compared to a specific amino acid sequence. Kit containing the membrane fusion sequence of. [Selection diagram] None |