| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0781 |
| filingDate |
2020-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59cb51141533e24b98237ec97c322446
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37f2c7f764d551d43f9e1b50efef9ccf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d03d62e635f09a18473e93facf18337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e826147dc4e960c7ade3a53009ed4f48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_459bb875e639bd335e9a1a006e19df83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a887d88d643b3ff222cbcafb62bbb438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_066312d9c7b2b2b0fb9fc710851e6217
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_716b0c4c0c5710ef8f392145fcb8e5a9 |
| publicationDate |
2020-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2020182490-A |
| titleOfInvention |
Mice expressing a limited immunoglobulin light chain repertoire |
| abstract |
PROBLEM TO BE SOLVED: To make a human epitope-binding protein containing a common light chain without relying on manipulating in vitro conditions, and instead using a more biologically reasonable method. The composition and method are provided. A genetically modified mouse expressing a human immunoglobulin heavy chain and a light chain variable domain, the mouse having a limited light chain variable repertoire; binding to a diverse repertoire of affinity matured human heavy chain variable domains. And a biological system for producing a human light chain variable domain that is expressed together; a method for producing a binding protein containing an immunoglobulin variable domain, the purpose of which is a mouse having a limited immunoglobulin light chain repertoire. There is provided a method comprising immunizing with an antigen of the above and using a mouse immunoglobulin variable region gene sequence for a binding protein that specifically binds to the antigen of interest. [Selection diagram] None |
| priorityDate |
2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |