| abstract |
PROBLEM TO BE SOLVED: To provide a method and a composition for improving cognitive function. The present invention uses synaptic vesicle protein 2A (SV2A) inhibitors and acetylcholinesterase inhibitors (AChEI), or a combination of pharmaceutically acceptable salts, hydrates, solvates, and polymorphic forms thereof. With respect to methods and compositions for improving cognitive function. Specifically, the present invention presents with SV2A inhibitors and AChEI in treating central nervous system disorders associated with cognitive dysfunction in subjects who require or are at risk for this disorder. Regarding the use of the combination of. This subject includes age-related cognitive impairment, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), prodromal AD, post-traumatic stress disorder (PTSD), psychiatric dysfunction, and muscle atrophy. Patients with, but not limited to, sexual sclerosis (ALS) and cognitive impairment associated with cancer treatment, or at risk thereof. [Selection diagram] Fig. 3 |