| abstract |
PROBLEM TO BE SOLVED: To provide an antibody capable of binding to TREM-1 and blocking its function. The present invention relates to an antibody capable of specifically binding to TREM-1, a protein expressed in monocytes, macrophages and neutrophils, and interfering with TREM-1 activation. Such antibodies are found to be useful in the treatment of individuals with inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. [Selection diagram] None |