| abstract |
PROBLEM TO BE SOLVED: To provide a method for detecting the presence of cancer in a mammal and a method for treating or preventing cancer. A chimeric antigen receptor (CAR) having antigen specificity for CD70, which comprises an antigen-binding / transmembrane domain containing a CD27 amino acid sequence lacking all or part of a CD27 intracellular T cell signaling domain. 4-1 BB intracellular T cell signaling domain; CD3ΞΆ intracellular T cell signaling domain; and optionally the CAR containing the CD28 intracellular T cell signaling domain, as well as nucleic acid, recombinant expression vector associated with the CAR. , Host cells, cell populations and pharmaceutical compositions. [Selection diagram] None |