| abstract |
PROBLEM TO BE SOLVED: To provide a method for producing a novel crystalline form E of pitavastatin calcium, a novel crystalline form E and a pharmaceutical composition containing the crystalline form. SOLUTION: (3R, 5S) -7- [2-cyclopropyl-4- (4-fluorophenyl) quinoline-3-yl] -3,5-dihydroxy having a characteristic peak in an X-ray powder diffraction pattern. Crystal polymorph A of -6 (E) -heptenoic acid hemicalcium salt was used as a raw material, suspended in 1,4-dioxane or methanol containing water as an auxiliary solvent, and the produced crystals were separated and dried. , A novel crystalline polymorph E having a characteristic peak in an X-ray powder diffraction pattern is produced. [Selection diagram] None |