| abstract |
PROBLEM TO BE SOLVED: To provide recombinant adeno-associated virus (rAAV) particles for use in delivering a heterologous nucleic acid to an individual's eye. Recombinant adeno-associated virus (rAAV) particles are formulated for vitreous administration of recombinant adeno-associated virus (rAAV) particles to an individual's eye, and the rAAV particles are a) VP1 numbering of AAVrh8R. An rAAV capsid containing an AAVrh8R capsid protein containing an amino acid substitution of A586 and / or T589 with arginine or lysine, numbered based on, and b) an rAAV vector containing the heterologous nucleic acid and at least one AAV inverted end repeat including. [Selection diagram] None |