| abstract |
PROBLEM TO BE SOLVED: To provide a novel histone deacetylase inhibitor. SOLUTION: A compound represented by the following formula or a pharmaceutically acceptable salt thereof. (Each R'is independently H or QR 1 ; each Q is independently bound, CO, CO 2 , NH, S, SO, SO 2 or O; each R 1 is independently H, C 1 to C 10 alkyl, C 2 to C 10 alkenyl, C 2 to C 10 alkynyl, aryl, heteroaryl, C 1 to C 10 cycloalkyl, halogen, C 1 to C 10 alkylaryl, C 1 to C 10 alkyl heteroaryl or C 1 to C 10 heterocycloalkyl; each L is an independently 5-10 member nitrogen-containing heteroaryl; W is a zinc-binding group; each R 2 is an independently H or C 1 to C 6 alkyl; R 3 is an aryl or heteroaryl.) [Selection diagram] None |