http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020158498-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1394e66eb648f9bf0a1f5507fe25b67b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2020-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4da8376d0e50a264e23e25f74dff3534 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f75835ac4e37777cd11f801fb81a104 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41046d5464faac4b338b8ca2c136cfcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a7a29c0aedd0cacce8774f564c7ee6e |
| publicationDate | 2020-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2020158498-A |
| titleOfInvention | Method for producing quinoline carboxylic acid derivative |
| abstract | PROBLEM TO BE SOLVED: To provide a method for industrially advantageously synthesizing a quinolinecarboxylic acid derivative represented by the formula (4), which is an intermediate for producing a quinolinecarboxamide derivative or a salt thereof, or a salt thereof. SOLUTION: Anilines represented by the following formula (1) are reacted with aldehydes represented by the formula (2) in the presence of a boron trifluoride-tetrahydrofuran complex or a boron trifluoride-diethyl ether complex. Subsequently, a method for producing a quinolinecarboxylic acid derivative represented by the formula (4) or a salt thereof, which comprises reacting α-keto acids represented by the formula (3). [In the formula, R 1 , R 2 , R 3 and R 4 may be the same or different, hydrogen atom, halogen atom, lower alkyl group, etc., R 5 is hydrogen atom, lower alkyl group, etc., R 6 is hydrogen. Atom, lower alkyl group, etc. ] [Selection diagram] None |
| priorityDate | 2019-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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