| abstract |
PROBLEM TO BE SOLVED: To provide EGFR-oriented CAR therapy for glioblastoma. Glioblastoma (GB) remains the most aggressive primary malignancies; brain metastases such as breast cancer brain metastases (BCBMs) are also of high grade and are associated with a poor prognosis. Adoption of immune cells modified by chimeric antigen receptor (CAR) has emerged as a promising anticancer approach, but the potential utility of CAR-engineered cells in treating brain cancer has not been investigated .. The present disclosure provides compositions and methods for using cells expressing CAR in the treatment of various cancers, including brain cancers such as GB and BCBM. [Selection diagram] None |