abstract |
PROBLEM TO BE SOLVED: To provide a method for producing an antibody containing a human Ig variable region in a non-human mammal, and further to provide a non-human animal model for producing such an antibody. The present invention relates to methods for producing human-non-human chimeric antibodies and chimeric antibody chains, antibodies and antibody chains thus produced, and derivatives thereof, including fully humanized antibodies; said antibodies. Compositions comprising antibody chains and derivatives, as well as cells, non-human mammals and vectors suitable for use in the methods are disclosed. [Selection diagram] None |