http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020147595-A

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filingDate 2020-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5bfefdb0b07ececf775f8d5c8933ebe7
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publicationDate 2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2020147595-A
titleOfInvention Pharmaceutical composition with improved stability
abstract PROBLEM TO BE SOLVED: To provide an injectable composition for delivery of a sustained-release drug and a method for producing the same. SOLUTION: A poly (D, L-lactide-co-) having a weight average molecular weight of 5,000 to 50,000 daltons, an acid value of less than 3 mgKOH / g, and a molar ratio of lactide / glycolide of 85/15. Glycolide) or poly (D, L-lactide) is purified until the content of residual lactide monomer is less than about 0.3% by weight, and the purified poly (D, L-lactide-co-glycolide) is purified. ) Or the poly (D, L-lactide) is reacted with N-methyl-2-pyrrolidone as a pharmaceutically acceptable organic solvent and a lactide monomer in the molecular structure to form a conjugate. A production method comprising a combination with goseleline and / or triptorelin, or a salt thereof, which can be used, and no acid additive is added when producing the composition. [Selection diagram] None
priorityDate 2014-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 783.