| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac08332f12dd47461c722320c873b914 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-41 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0618
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0037 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-30 |
| filingDate |
2020-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeaa41153163d2348f1e060e54cf3ac7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b330222739f4a94e8d18fd35a4c0de1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_640b08653b603d6f2ab79deee9e43687 |
| publicationDate |
2020-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2020146055-A |
| titleOfInvention |
Method for producing glandular pituitary gland or its precursor tissue |
| abstract |
PROBLEM TO BE SOLVED: To provide a method for in vitro inducing a glandular pituitary gland or a precursor tissue thereof from human pluripotent stem cells. SOLUTION: Agglomerates of human pluripotent stem cells are suspended and cultured in a medium containing an osteogenic factor signal transduction pathway activator and a Shh signal pathway activator to obtain hypothalamic neuroepithelial tissue and epidermal ectoderm. Human cell agglomerates containing, and further obtained human cell agglomerates containing hypothalamic neuroepithelial tissue and epidermal ectoderm in a medium containing an osteogenic factor signaling pathway activator and a Shh signaling pathway activator. Further suspension culture induces the formation of pituitary placode and / or Rathke's pouch in the epidermal ectoderm, 1) hypothalamic neuroepithelial tissue, and 2) humans containing pituitary placode and / or Rathke's pouch. Obtain cell aggregates. [Selection diagram] Fig. 1 |
| priorityDate |
2014-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |