| abstract |
PROBLEM TO BE SOLVED: To provide an effective linker containing a self-destructive group, which is more stable in plasma, stable in circulation, and capable of easily releasing a drug in cancer cells to exert the effect of the drug. Providing a drug conjugate to have. SOLUTION: A drug conjugate containing a self-destructive group represented by the following formula. (In the formula, G is a glucuronic acid moiety or a derivative thereof, A is a hydrocarbyl, a biomaterial, etc., B is a hydrocarbyl, W is an electron-attracting group, Z is an H, an alkyl group, etc., n is an integer of 1 to 3. L represents a linker, and R 1 and R 2 independently represent H, an alkyl group, etc.) [Selection diagram] FIG. 10 |