| abstract |
PROBLEM TO BE SOLVED: To provide a fluorescence-based small molecule for imaging amyloid accumulation, which is a prominent feature of many neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease, Down's syndrome, and Creutzfeldt-Jakob disease (CJD). A compound of formula I. (In the formula, EDG is an electron donating group, EWG is an electron attracting group, and WSG is a water-soluble group.) [Selection diagram] None |