| abstract |
PROBLEM TO BE SOLVED: To provide a compound capable of reversing and / or preventing an NMDAR antagonist-induced cognitive disorder (for example, an NMDAR antagonist-induced disorder in novel object recognition; for example, induced by repeated administration of an NMDAR antagonist). It features a combination of NMDA regulatory compounds. The disclosure features a combination comprising one or more NMDA antagonists and GLYX-13 (each of which is sometimes referred to herein as a "component"). The beneficial effect of the combination is, in part, that administration of GLYX-13 (eg, single dose) is NMDAR antagonist-induced cognitive impairment (eg, NMDAR antagonist-induced cognitive impairment in novel object recognition; eg, repetition of NMDAR antagonists. Based on the discovery that dosing-induced) can be reversed and / or prevented. [Selection diagram] Fig. 1 |