| abstract |
PROBLEM TO BE SOLVED: To provide an antifibrotic pyridinone. The present application relates to polycyclic compounds having a pyridinone core or a core derived from a pyridinone, including substituted pyridinones, 5,6- and 6,6-bicyclic heterocycles and substituted pyridine-thiones. The present application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments containing these compounds, and methods of treating, preventing or diagnosing diseases, disorders or conditions associated with fibrosis. .. In some such embodiments, the fibrotic condition is selected from the group consisting of pulmonary fibrosis, skin fibrosis, pancreatic fibrosis, liver fibrosis, and renal fibrosis. [Selection diagram] None |