| abstract |
Antibodies that bind complement C1s protein; and methods of making and using nucleic acid molecules and compositions encoding said antibodies. An isolated humanized monoclonal antibody that specifically binds complement component 1s (C1s). An isolated humanized monoclonal antibody comprising a humanized VH framework region. An isolated humanized monoclonal antibody comprising a humanized VL framework. Anti-complement C1s antibody inhibits the proteolytic activity of C1s. Also, compositions containing antibodies and methods of making and using the antibodies, nucleic acid molecules, and compositions. [Selection diagram] Figure 2 |