| abstract |
PROBLEM TO BE SOLVED: To provide a long-acting polymer delivery system. A composition comprising a delivery vehicle or delivery system and an active agent dispersed in the delivery vehicle or system, wherein the delivery vehicle or system comprises a polyorthoester polymer and a polar aprotic solvent. .. Also disclosed are low viscosity delivery systems for administering the active agents. The low viscosity delivery system has a polyorthoester polymer, a polar aprotic solvent, and a solvent containing a triglyceride viscosity reducing agent. The compositions described are for example amide or anilide type local anesthetics and non-steroids classified as “caine” with associated methods for the treatment of post-operative pain or for the prophylactic treatment of pain. System anti-inflammatory drugs (NSAIDs). The compositions are suitable for delivery by, for example, direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural). [Selection diagram] Fig. 1A |