abstract |
PROBLEM TO BE SOLVED: To provide a monoclonal antibody against BCMA. The present invention relates to a novel antibody against BCMA, its production and use. The present invention includes monoclonal antibodies that specifically bind to human B cell maturation antigen (BCMA). The antibody according to the present invention contains the same CDR regions as the antibody 83A10 as the CDR3H region and the CDR3L region. The antibody according to the invention comprises in one embodiment the same CDR regions as antibody 83A10 as CDR3H and CDR3L regions, but is particularly potent in killing MM cells in the patient's bone marrow aspirate compared to antibody 83A10. And show efficient advantages. [Selection diagram] None |