| abstract |
PROBLEM TO BE SOLVED: To provide a method for enhancing the function of immune cells by activating various immune cells ex vivo, and to provide immune cells with enhanced function. Furthermore, it provides a method for evaluating cell multifunctionality relating to immunity. According to one of the biguanide antidiabetic agents selected from metformin, phenformin, and buformin, immune cells are increased by increasing CD8 + T cells having high IL-2, TNFα, and IFNγ-producing ability. The multi-functionality of can be enhanced. The multifunctionality of cells related to immunity can be evaluated by comparing the multifunctionalities of the immune cells treated with the biguanide antidiabetic drug and the control immune cells not treated with the biguanide antidiabetic drug. .. When the immune cells treated with the biguanide antidiabetic drug have significantly improved multifunctionality as compared to the control, it can be evaluated that the sensitivity of the immune cells to the drug is improved. [Selection diagram] None |