| abstract |
PROBLEM TO BE SOLVED: To provide a costimulatory chimeric antigen receptor T cell targeting interleukin-13Rα2 (IL13Rα2) for antitumor treatment, and a costimulatory chimeric antigen receptor T cell targeting L13Rα2. A chimeric transmembrane immunoreceptor comprising an extracellular domain comprising IL-13 that binds to interleukin-13Rα2 (IL13Rα2), or a variant thereof, a transmembrane region, a costimulatory domain, and an intracellular signaling domain. Body (CAR). [Selection diagram] Figure 1 |