| abstract |
PROBLEM TO BE SOLVED: To provide improved pluripotent cells and microvascular tissues, and methods for using the same. The present disclosure provides compositions with improved biological activity and methods of use in the treatment of pain associated with disease or tissue damage and disease states. Embodiments of the invention include isolated pluripotent cells, engineered microvascular tissue, cell membranes obtained or derived from the cells or tissues, wherein the cells, tissues, or membranes are neovascularized or Has anti-inflammatory activity. Embodiments of the invention include compositions that are exposed to treatments that typically reduce the efficacy of cells or proteins, but surprisingly enhance the biological activity of cells or tissues. [Selection diagram] None |