abstract |
PROBLEM TO BE SOLVED: To provide a compound, a crystalline form, for treating a disease affected or mediated by an androgen receptor. SOLUTION: The disorder or condition is anemia, anorexia, arthritis, bone disease, musculoskeletal dysfunction, cachexia, weakness, age-related functional decline in the elderly, growth hormone deficiency, hematopoietic disorders, hormone replacement, gonads. Sarcopenia, including sarcopenia in hypofunction, muscle weakness and/or muscle function, muscular dystrophy, post-operative muscle mass loss, muscular atrophy, neurodegenerative disease, neuromuscular disease, obesity, osteoporosis, chronic obstructive pulmonary disease, And a crystalline form of 6-[(4R)-4-methyl-1,1-dioxide-1,2,6-thiadiadinan-2-yl]isoquinoline-1-carbonitrile selected from the group consisting of , Or a pharmaceutically acceptable salt thereof for use in combination with a second pharmaceutically active ingredient or pharmaceutically acceptable salt thereof. [Selection diagram] Figure 1 |