| abstract |
One of the objects of the present invention is to bind a payload, such as a drug, a toxic substance, a cytokine, a marker, etc., to an immunoligand to generate a site-specific complexed antibody-drug complex (ADC). , Preferably a full-length monoclonal antibody, is provided with an efficient method of binding low molecular weight toxins. The invention relates to a method of producing an immunoligand/payload complex, which method comprises binding a payload to an immunoligand using a sequence-specific transpeptidase or its catalytic domain. [Selection diagram] Fig. 6b |