abstract |
PROBLEM TO BE SOLVED: To provide a mucoadhesive device for suppressing opioid abuse. An abuse deterrent mucoadhesive device for use in managing pain or opioid dependence, the mucoadhesive layer comprising an effective amount of buprenorphine buffered to a pH of about 4.0 to about 6.0; and The device comprising a backing layer buffered to a pH of about 4.0 to about 4.8. [Selection diagram] Figure 1 |