| abstract |
PROBLEM TO BE SOLVED: To provide an ICOS binding protein containing immunotherapy and its related costimulatory T cell receptor (ICOS) agonist antibody in the treatment of human diseases. One of the CDRH1, CDRH2, CDRH3, CDRL1, CDRL2 and/or CDRL3 of an amino acid sequence consisting of a particular sequence or the direct equivalent of each CDR having up to two amino acid substitutions in said CDR. An ICOS-binding protein or an antigen-binding portion thereof, which comprises the above. [Selection diagram] None |