| abstract |
An eye drop bottle that eliminates patient exposure to preservatives in delivered eye drops, particularly BAK (benzalkonium chloride), while retaining the BAK in the contained formulation. Provided are multiple dose devices and methods that ensure sterility. A BAK removal device is constructed as a plug of hydrophilic polymer gel microparticles exhibiting a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymer gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm, the plug has a surface area of 30 mm 2 to 2 mm 2 and the length of 2 mm to 25 mm, and the hydrophilic polymer gel microparticles have a pore radius of 3 to 60 μm. .. [Selection diagram] Figure 1 |