| abstract |
PROBLEM TO BE SOLVED: To provide a nanoparticle complexed with a biopolymer drug, which is configured to treat, prevent, or ameliorate various types of disorders, and a synthetic method thereof. A composition comprising nanoparticles, wherein an antigen is complexed with the nanoparticles and an adjuvant is complexed or mixed with the nanoparticles. The nanoparticles are selected from the group consisting of sHDL nanoparticles, fullerenes and the like. The antigen is selected from the group consisting of an antigen for PCSK9 and an antigen for gp100 melanoma. Adjuvants are CPG, polyIC, poly-ICLC, 1018 ISS, aluminum salt, Amplivax, AS15, BCG, CP-870,893, CpG7909, CyaA, dSLIM, GM-CSF, IC30, IC31, Imquiquimod, ImuFactISP32IS. , ISS, ISCOMATRIX, Juvlmmune, and the like. [Selection diagram] Figure 2 |