abstract |
PROBLEM TO BE SOLVED: To provide a method for treating nasal polyps. A pharmaceutical composition containing an antibody or an antigen-binding fragment thereof that specifically binds to interleukin-4 receptor (IL-4R). An antibody or antigen-binding fragment thereof comprises heavy and light chain CDR sequences from a particular sequence heavy chain variable region (HCVR) and light chain variable region (LCVR) sequence pair. The subject has one or more of sinusitis, rhinitis, asthma, aspirin hypersensitivity, nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity, or is undergoing surgery for nasal polyps. The subject has chronic rhinosinusitis. The antibody or antigen-binding fragment thereof is administered at a dose of 0.1 mg to 600 mg. [Selection diagram] None |