| abstract |
PROBLEM TO BE SOLVED: To provide a chiral-substituted pyrazolylpyrrolo [2,3-d] pyrimidine useful as a JAK inhibitor for the treatment of inflammatory diseases, myeloproliferative disorders and the like. A method for producing compound XII, comprising reacting compound X with XIII in the presence of a palladium catalyst, a base and a solvent to form XII, wherein X 2 is Tosylate, triflate, I, Cl or Br; R c and R d are independently H or C 1-6 alkyl; or R c and R d are O to which they are attached and B to which O is attached. Taken together with to form a 5 to 6 membered heterocycle, which heterocycle is optionally substituted with 1 to 4 C 1-4 alkyl groups; P 1 and P 2 are independently Is a protecting group). [Selection diagram] None |