| abstract |
PROBLEM TO BE SOLVED: To provide a drug acting as an allosteric modulator of hemoglobin and an intermediate thereof which can be used for the treatment of a disorder mediated by hemoglobin and a disorder in which an increase in tissue oxygenation can be effective. A substituted benzaldehyde of the following formula and derivatives thereof. [Wherein Q is selected from the group consisting of aryl, heteroaryl and heterocycloalkyl, each optionally substituted with 1 to 3 Ra; Y is O or CR 1a R 1b , wherein R 1a is H or halo and R 1b is selected from the group consisting of H, halo, and OH; X consists of O,> CH (CH 2 ) n R 8 and C (R 9 ) 2. Selected from the group. R 6 and R 7 together form an oxo or aldehyde protecting group. ] [Selection diagram] None |