abstract |
PROBLEM TO BE SOLVED: To provide an antigen-binding molecule having agonist activity to TNF superfamily or TNF receptor superfamily which activates immune cells and exhibits an excellent antitumor effect while avoiding toxicity, and the antigen-binding molecule as an active ingredient. And a method for treating cancer using the pharmaceutical composition. An antigen binding comprising the following domains: (1) a cancer-specific antigen binding domain, and (2) a tumor necrosis factor (TNF) superfamily binding domain or a tumor necrosis factor (TNF) receptor superfamily binding domain. molecule. [Selection diagram] Fig. 3 |