| abstract |
PROBLEM TO BE SOLVED: To provide an antibody or an antigen-binding fragment thereof which binds to human TIGIT (T cell immunoreceptor having Ig and ITIM domain), and use of these antibody or fragment in the treatment of cancer or chronic viral infection. Regarding binding with human TIGIT, 14B2, 13E6, 6F9, 11G11, 10C9, 16F6, 11C9, 27A9, 10D7, 20G6, 24E8, 24G1, 27F1, 15A6, 4E4, 13D1, 9B11, 10B8, 22G2, 19H2. An isolated antibody or antigen-binding fragment thereof that competes with one or more antibodies selected from the group consisting of :, 8C8, 17G4, 25E7, 26D8 and 16A8. Combination therapy with inhibitors of other immunoregulatory receptor interactions such as PD-1 / PD-L1 interactions. A polynucleotide encoding an antibody, an expression vector containing the polynucleotide, a cell containing the vector, and a method for producing an antibody from the cell. [Selection diagram] None |