abstract |
PROBLEM TO BE SOLVED: To provide a method for selecting a compound that binds to and regulates histone acetyltransferase protein. Further, administering a HAT-activating compound to a patient to treat neurodegenerative diseases, accumulated amyloid-beta peptide deposits, Tau protein levels, and / or symptoms associated with alpha-synuclein accumulation, and cancer. To provide a method. The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt or hydrate thereof. Wherein: R 1 is H or CF 3 , R 2 is H, Cl, or CN; R 3 is H, O-methyl, O-ethyl, etc .; R 4 is , H; C (═O) NH-phenyl (substituted by halo or CF 3 ); R 5 is H, C 1 -C 5 -alkyl, OH, OCH 3 , O-ethyl, OCH 2 CH 2 N (CH 3 ) 2 , etc.] [Selection diagram] None |