abstract |
PROBLEM TO BE SOLVED: To provide a bispecific antibody comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3. HVR-H1, comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, wherein the first antigen-binding site contains a specific amino acid sequence, The second antigen-binding site containing a VH domain containing HVR-H2, HVR-H3 and a VL domain containing HVR-L1, HVR-L2, and HVR-L3 containing a specific amino acid sequence, and specifically binding to TIM3. Contains a VH domain containing HVR-H1, HVR-H2, and HVR-H3 containing a specific amino acid sequence, and a VL domain containing HVR-L1, HVR-L2, and HVR-L3 containing a specific amino acid sequence. . [Selection diagram] None |