| abstract |
A peptide that blocks leukocyte recruitment and methods of use are provided. Kind Code: A1 Disclosed are novel peptides containing SEQ ID NO: 1 and modifications thereof, which are effective in blocking leukocyte recruitment. The disclosed peptides are useful for treating diseases associated with leukocyte recruitment, for example, for inhibiting metastasis of solid tumors to the liver and lungs, and for treating sepsis. Also disclosed are methods of screening for compounds that have the ability to block leukocyte recruitment. Also provided is a pharmaceutical composition comprising an isolated peptide comprising SEQ ID NO: 1 and a pharmaceutically acceptable carrier. [Selection diagram] None |