| abstract |
An isolated humanized antibody having improved stability, particularly deamidation stability of HVR-H2 and HVR-L1 of heavy chain HVR and light chain HVR, in a humanized anti-human CD19 antibody. . A specific amino acid sequence mutated based in part on the finding that one mutation is sufficient to eliminate multiple deamidation hot spots in a humanized anti-human CD19 antibody. An antibody that specifically binds to human CD19. [Selection diagram] None |