| abstract |
An object of the present invention is to provide an inhibitor of an E1 activating enzyme. The present invention relates to a compound of formula (I) which inhibits an E1 activating enzyme, a pharmaceutical composition comprising the compound and a method of using the compound. The compounds are useful in treating diseases, particularly cell proliferative disorders, including cancer, inflammatory and neurodegenerative disorders, and inflammation associated with infection and cachexia. The compounds are useful for inhibiting E1 activity in vitro and in vivo, and are useful for treating cell proliferative disorders, particularly cancer, and for treating other disorders related to E1 activity. [Selection diagram] None |