abstract |
An object of the present invention is to provide a novel adrenomedullin derivative capable of acting for a longer period of time than natural adrenomedullin. The present invention provides a compound represented by the formula (I): AL n -B (I) [Where, A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, B is a peptide moiety derived from adrenomedullin or a modified form thereof having adrenomedullin activity, However, the peptide part B is bonded to the modifying group A or the linking group L via its N-terminal amino group. ] Or a salt thereof, or a hydrate thereof. [Selection diagram] Fig. 1 |