| abstract |
An object of the present invention is to provide an antibody, an antibody chain, a chimeric human-non-human antibody, a chimeric antibody chain, and a fully humanized antibody. The invention relates to a non-human genome comprising a human VH, D and JH gene segment upstream of the constant region of the heavy chain locus and / or a human VL and JL gene segment upstream of the constant region of the light chain locus. A human vertebrate (e.g., a mouse or rat) or cell, wherein the vertebrate or cell is capable of expressing an immunoglobulin heavy and / or light chain comprising human VH and VL domains, respectively; Is operably linked to its constant region, the heavy chain locus comprises a human 01 allele VH gene segment that can recombine with the human D and JH gene segments to produce a VH domain, and the light chain locus comprises Contains a human 01 allele VL gene segment that can recombine with a human JL gene segment to produce a VL domain, or A non-human vertebrate or cell capable of developing in a vertebrate expressing the chain and / or light chain. [Selection diagram] None |