| abstract |
An easily administrable and fast-acting drug formulation of dihydroergotamine for intra-nasal administration for alleviating migraine symptoms. A powder formulation comprising dihydroergotamine (DHE) or a pharmaceutically acceptable salt thereof, comprising a microcrystalline cellulose component comprising at least 15% of the total weight of the formulation is presented. . Also provided is a method comprising intranasally administering a powder formulation comprising dihydroergotamine or a pharmaceutically acceptable salt thereof. Use of the presented method for treating headache, e.g., for the immediate treatment of headache, including migraine, e.g., for the acute treatment of migraine with or without aura Can be. [Selection diagram] None |