abstract |
An object of the present invention is to find a substance that does not affect normal blood vessels and normalizes the permeability of blood vessels at a diseased site in a disease associated with angiogenesis abnormality such as a solid cancer, and to provide a novel use of the substance. Make it an issue. Kind Code: A1 A drug delivery-enhancing agent for promoting the delivery of a therapeutic agent for a disease associated with angiogenesis to a diseased site containing a substance that activates a lysophosphatidic acid receptor as an active ingredient, a lysophosphatidic acid receptor For treating diseases associated with angiogenesis containing as an active ingredient a substance that activates liposomes, a vascular normalizing agent containing as an active ingredient a substance that activates lysophosphatidic acid receptor, and blood vessels at diseased sites A method for screening a therapeutic drug for a disease associated with angiogenesis, which comprises selecting a substance that activates a lysophosphatidic acid receptor specifically expressed in endothelial cells. [Selection diagram] None |